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G Protein Coupled Receptors Biology Essay, Gprotein essay

Gprotein essay

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The catalytic subunits of some second messenger  –  dependent protein kinases are further activated by phosphorylation of specific residues within the phosphorylation lip . As in the case of MAP kinases, when the lip is unphosphorylated, it inhibits binding of ATP or protein substrates, or both. Phosphorylation induces a conformational change leading to effective binding of both ATP and protein substrates. X-ray crystallographic analyses have revealed that many different protein kinases share a common threedimensional structure similar to that of MAP kinase shown in Figure 20-30 .

Rhodopsin, a chromoprotein is fundamentally a protein which is linked to a pigment transporting substance that is contained in the light- sensitive cells of the rod type in the retina of the oculus. The pigment which contains the part of visual purple is retinal, a substance formed by oxidization of vitamin-A. opsin is the protein portion. Retinal and opsin in dark makes visual purple but the procedure is reversed in a bright visible radiation.

In biological membranes the signal detection and transmission is initiated by the interaction of a chemical or physical stimulus with a specific membrane receptor which, in turn, becomes activated and initiates a chain of intracellular reactions that result in modulation of target protein activity. G-Protein Coupled Receptors are a superfamily of such membrane proteins that transmit a signal by coupling to heterotrimeric-binding proteins, which consist of three subunits (α, β and γ). Rhodopsin is a member of GPCRs superfamily which is pharmacologically important.

Although all GPCRs are thought to span the membrane seven times and hence to have similar three-dimensional structures, their amino acid sequences generally are quite dissimilar. For example, the sequences of the closely related β 1 - and β 2 -adrenergic receptors are only 50 percent identical; the sequences of the α- and β-adrenergic receptors exhibit even less homology . The specific amino acid sequence of each receptor determines which ligands it binds and which G proteins interact with it.

GPR12 belongs to the orphan GPCR family which is the same of the GPR3 and GPR6 ( Ignatov et al., 2003a ; Ignatov et al., 2003b ). According to Horn et al. , GPR12 belongs to the   GPCRs, Class A Rhodopsin-like subfamily with all other Orphan GPCR receptors ( Horn et al., 2003 ).

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The major type of subunit is the G alpha subunit. This subunit stimulates adenlyl cyclase, and it is assocciated with hormones like glucagon, adrenaline, leutenizing hormones, parathyroid (PTH) hormones, and adrenocorticotropic (ACTH) hormone. Adenlyl cyclase is important in the Cyclic AMP Pathway used by our cells to convert ATP into cAMP. G alpha is the main subunit because it is the component of the g-protein that binds GTP and GDP, which is the final component of g-protein activation.

Diagram of the biuret reaction. By reducing the copper ion from cupric to cuprous form, the reaction produces a faint blue-violet color.

Other interference may come from the buffer used when preparing the protein sample. A high concentration of buffer will cause an overestimated protein concentration due to depletion of free protons from the solution by conjugate base from the buffer. This will not be a problem if a low concentration of protein (subsequently the buffer) is used. [ citation needed ]


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Analysis of G-Protein Coupled Receptor 12 - UK Essays

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g protein essay
g protein essay

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